Noncontact true temperature measurement, 2

A laser pyrometer was developed for acquiring the true temperature of a levitated sample. The reflectivity is measured by first expanding the laser beam to cover the entire cross-sectional surface of the diffuse target. The reflectivity calibration of this system is determined from the surface emissivity of a target with a blackbody cavity. The emissivity of the real target can then be calculated. The overall system constant is obtained by passively measuring the radiance of the blackbody cavity (emissivity = 1.0) at a known, arbitrary temperature. Since the photosensor used is highly linear over the entire operating temperature range, the true temperature of the target can then be computed. The latest results available from this on-going research indicate that true temperatures thus obtained are in very good quantitative agreement with thermocouple measured temperatures

Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate.

The title mol-ecule, C(22)H(23)N(3)O(2), was obtained via an intra-molecular cyclo-addition of an azomethine ylide and an alkene tethered by a benzimidazole unit. The benzoimidazole unit is essentially planar, with an r.m.s. deviation of 0.0087 Å from the nine constituent atoms. It has a cis fusion of the two pyrrolidine rings as well as a cis ester appendage. The two pyrrolidine rings rings have envelope conformations. The crystal packing is stabilized by aromatic π-π stacking of parallel benzimidazole ring systems, with a centroid-to-centroid distance of 3.518 (6) Å. Weak inter-molecular C-H⋯O contacts may also play a role in the stability of the packing

Noncontact temperature pattern measuring device

Laser pyrometer techniques are utilized to accurately image a true temperature distribution on a given target without touching the target and without knowing the localized emissivity of the target. The pyrometer utilizes a very high definition laser beam and photodetector, both having a very narrow focus. The pyrometer is mounted in a mechanism designed to permit the pyrometer to be aimed and focused at precise localized points on the target surface. The pyrometer is swept over the surface area to be imaged, temperature measurements being taken at each point of focus

Structural characterisation of pre-processed thermoplastic protein derived from bloodmeal

Additives are required to convert bloodmeal powder into an extrudable thermoplastic protein-based bioplastic. These include a protein denaturant, a surfactant, a reducing agent and plasticisers. The objective of this work was to assess the structural changes induced in bloodmeal by these additives prior to extrusion. Structure was investigated using Fourier transform infrared (FT-IR) spectroscopy, wide angle X-ray scattering (WAXS) and synchrotron light based FT-IR microspectroscopy. FT-IR results suggested the additives reduced α-helical content. The shape of the amide I region (1600 – 1700 cm⁻¹, representing carbonyl group stretching in the protein backbone) is known to depend on protein secondary structures. Bloodmeal showed a broad, convoluted peak in this region, with a maximum in the range 1648 – 1658 cm⁻¹, associated with α-helices. With processing additives, a dip was seen in the α-helix region, with twin peaks emerging either side of it. Urea, one of the additives, also absorbs in the amide I region and may also contribute to a change in its shape. Analysis of the amide 3 region supported a reduction in the ratio of α helices to β sheets. Further support of structural changes was shown by WAXS. The additives decreased the sharpness of peaks corresponding to 4.8 Å and 10 Å, thought to represent intra-helix spacing and inter-helix packing respectively. FT-IR microspectroscopy at the Australian Synchrotron enabled spatial variations in secondary structure to be explored using peaks in the amide 3 region. Spatial distribution of secondary structure was detected in bloodmeal and thermoplastically modified bloodmeal prior to extrusion (PPM-TEG). Bloodmeal showed domain separation on the approximate order of 10 μm, whilst PPM-TEG appeared to have larger phases and overall reduced α-helical content, relative to beta sheets

Plasticization of Bloodmeal-based Thermoplastics

Water is the most common plasticizer for proteinbased thermoplastics, lowering the softening point to a allow processing without excessive degradation. The biggest drawback of using water a plasticizer is that water easily evaporates from the material during use or storage. This leads to embrittlement and loss of functionality over time. In this study a series of high molecular mass plasticizers were evaluated for their efficiency in plasticizing bloodmeal-based thermoplastics. It was found that propylene glycol, di and tri-ethylene glycol were most efficient in increasing the material’s ductility, as measured by elongation at break. Using 10 parts plasticizer per hundred bloodmeal (pphBM) in combination with 10 pphBM urea gave optimal results in terms of Young’s modulus, tensile strength and processability. The mechanical properties of plasticized samples showed a stronger dependency on moisture content, compared to unplasticized samples and reached higher equilibrium moisture content in a shorter time. Using 10 pphBM TEG as plasticizer in resulted in a plastic material with a Young’s modulus of 869 MPa, tensile strength of 14.7 MPa and an elongation at break of 46%

Ingested bovine amniotic fluid enhances morphine antinociception in rats

Ingestion by rats of rat placenta or amniotic fluid enhances opioid-mediated, or partly opioid-mediated, antinociception produced by morphine injection, vaginal or cervical stimulation, late pregnancy, and foot shock. This phenomenon is believed to be produced by a placental\ud opioid-enhancing factor (POEF). Ingestion by rats of human or dolphin placenta has also been shown to enhance opioid antinociception, suggesting that POEF may be common to many mammalian species. We tested bovine amniotic fluid (BAF) for its capacity to enhance morphine antinociception in female Long-Evans rats, as determined by percentage change from baseline tail-flick latency in response to radiant heat, and we report that 0.50 mL BAF effectively enhanced morphine antinociception but did not by itself produce antinociception. The efficacy of POEF across species suggests that POEF may have been functionally (and structurally) conserved during evolution. Furthermore, the availability of POEF at parturition, as well as its ability to enhance pregnancy-mediated antinociception without\ud disrupting maternal behavior, offers a tenable explanation for the long-debated ultimate causality of placentophagia

Changing the view:towards the theory of visualisation comprehension

The core problem of the evaluation of information visualisation is that the end product of visualisation - the comprehension of the information from the data - is difficult to measure objectively. This paper outlines a description of visualisation comprehension based on two existing theories of perception: principles of perceptual organisation and the reverse hierarchy theory. The resulting account of the processes involved in visualisation comprehension enables evaluation that is not only objective, but also non-comparative, providing an absolute efficiency classification. Finally, as a sample application of this approach, an experiment studying the benefits of interactivity in 3D scatterplots is presented

Novel diabetes drugs and the cardiovascular specialist

Recently, treatment with 2 newer classes of type 2 diabetes drugs were found to reduce events in patients with diabetes and cardiovascular (CV) disease, a group common in cardiology clinics. The sodium-glucose cotransporter 2 inhibitor, empagliflozin, markedly and rapidly reduced CV death and heart failure hospitalization, likely with hemodynamic/metabolic-driven mechanisms of action. More recently, the glucagon-like peptide–1 receptor agonists liraglutide and semaglutide also reduced CV death and/or major adverse CV events, but did so more slowly and did not influence heart failure risks, suggesting alternative mechanisms of benefit. We will discuss drug therapy for diabetes relative to CV risk, briefly summarize key findings of CV benefit from recent trials, discuss potential mechanisms for benefits of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide–1 agonists, and suggest how such drugs might be embraced by CV specialists to reduce CV events and mortality in their patients

Farm-gate nitrogen balances on intensive dairy farms in the south west of Ireland

peer-reviewedNitrogen management and farm-gate N balances were evaluated on 21 intensive dairy farms in the south west of Ireland for each of four years (2003 to 2006). The mean annual stocking density was equivalent to 202 kg/ha (s.d. 29.6) of N excreted by livestock on the farm. The mean annual farm-gate N surplus (imports – exports) declined between 2003 and 2006 (277 to 232 kg/ha, s.e. 6.8; P < 0.001) due to a decline in annual N imports (fertilizer, feed and imported manures; 335 to 288 kg/ha, s.e. 6.9; P < 0.001). Overall annual fertilizer N use on the farms decreased during the study period (266 to 223 kg/ha, s.e. 6.5; P < 0.001) mainly due to lower inputs for the first application in spring and for the production of first-cut silage. These decreases were partly offset by applying more slurry in spring for early grazing and for first-cut silage. The introduction of white clover resulted in lower N imports on four farms. Export of N from farms was unaffected by reductions in N imports. The mean efficiency of N use tended to increase over time (0.18 in 2003 to 0.20 in 2006). The large variation in quantities of fertilizer N applied on farms with similar stocking densities suggests potential for further improvements in the efficiency of N use. In terms of fertilizer N use, complying with S.I. No. 378 of 2006 did not require major changes in the N management practiceson 19 of the farms.This project was part-funded by the European Research and Development Fund under INTERREG IIIB: Green Dairy Project N° 100 and partly by the Dairy Levy. Financial support for post-graduate students involved in this study was provided by the Teagasc Walsh Fellowship Scheme